KASH5 and MMP14

Data Source:
BioGRID (two hybrid)

		KASH5	MMP14
Description		KASH domain containing 5	matrix metallopeptidase 14
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Lateral Element Nuclear Outer Membrane Integral Component Of Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Meiotic Spindle Pole	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton
	Molecular Function	Protein Binding Identical Protein Binding Dynein Complex Binding	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding Metalloaminopeptidase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Actin Filament Organization Homologous Chromosome Pairing At Meiosis Spermatogenesis Telomere Localization Oogenesis Spindle Assembly Spindle Localization Microtubule Cytoskeleton Organization Involved In Homologous Chromosome Segregation Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation	Skeletal System Development Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Response To Organic Cyclic Compound Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Craniofacial Suture Morphogenesis Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant
Pathways			Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs			Marimastat
Diseases
GWAS			Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		112 interacting genes: ABHD1 ADIPOQ ANKRD46 ATF7 BAG5 BCL2L2 BET1 C14orf180 CCDC120 CCDC87 CDC73 CDKL3 CIB3 CLDN8 CMTM5 CRABP2 CTXN3 CWF19L2 CXCL16 CXCL9 CYBC1 DERL1 DNAJC30 EFNA5 EMD FAM161A FAM241B FAM50B FAM90A1 FATE1 FIS1 FRA10AC1 FTCD FXYD3 GABARAPL2 GALNT2 GIMAP5 GOSR2 GPATCH4 GPR25 HMOX1 ITGAM ITM2B JAGN1 KDM1A LARP1 LAT LENG1 LHFPL5 LMNA LRCH4 MALL MARCHF2 MFSD5 MMP14 MOSPD3 MS4A1 MTX2 NRIP3 NSG1 NTAQ1 OLFM4 PDGFRA PGAP2 PGRMC1 PIGU PLP2 PLPP6 PPP1R18 RIPPLY2 RNF146 RSPH14 RSRC2 RTP2 SENP2 SERP2 SGTA SHMT2 SLC30A2 SLC35B4 SLC41A1 SLC41A2 SLC5A4 SLN SMCO4 SNAP47 STBD1 STX12 STX5 TCF25 TMEM11 TMEM147 TMEM14C TMEM19 TMEM199 TMEM41A TMEM86A TMPRSS4 TNF TRAF3IP3 TRARG1 TSHZ3 TTC23 UPK1B UPK2 VAMP1 VAMP2 VAMP4 VTI1B ZC2HC1C ZFPL1 ZNF250	35 interacting genes: ACAN ADI1 AQP6 BCAR1 C1QBP CAV1 CCL7 CLDN1 EBP ELOVL4 F11R F12 FHL3 FURIN HSD17B13 ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 MSMO1 PLLP RRAD SDC1 SPOCK1 SPOCK3 STOM TIMP2 TIMP3 TIMP4 TMEM31 ZUP1
Entrez ID		147872	4323
HPRD ID		08134	02856
Ensembl ID		ENSG00000161609	ENSG00000157227
Uniprot IDs		Q8N6L0	P50281
PDB IDs		6R2I	1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?
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