RAD9B and RAD17

Data Source:
HPRD (in vitro, in vivo)

		RAD9B	RAD17
Description		RAD9 checkpoint clamp component B	RAD17 checkpoint clamp loader component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Checkpoint Clamp Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex
	Molecular Function	Protein Binding 3'-5' Exonuclease Activity	Chromatin Binding DNA Clamp Loader Activity Protein Binding ATP Binding
	Biological Process	DNA Replication Checkpoint DNA Replication DNA Repair Intra-S DNA Damage Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Regulation Of Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163)
Interacting Genes		5 interacting genes: HUS1 HUS1B RAD1 RAD17 RAD9A	15 interacting genes: ATM ATR HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20
Entrez ID		144715	5884
HPRD ID		12221	09124
Ensembl ID		ENSG00000151164	ENSG00000152942
Uniprot IDs		A0A024RBJ5 A0A024RBN9 B4DX60 B4DYM6 J3KPN7 Q6WBX8	O75943
PDB IDs
Enriched GO Terms of Interacting Partners?
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