CRHR2 and GPR35

Data Source:
BioGRID (two hybrid)

		CRHR2	GPR35
Description		corticotropin releasing hormone receptor 2	G protein-coupled receptor 35
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Axon Terminus	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity	G Protein-coupled Receptor Activity C-X-C Chemokine Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Chemokine-mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Neuronal Action Potential
Pathways		G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production	Class A/1 (Rhodopsin-like receptors)
Drugs			Furosemide Pyrantel Kynurenic Acid
Diseases
GWAS		Type 2 diabetes ( 24509480 30297969)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 25489960) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		7 interacting genes: APP CRH GPR35 MALL UCN UCN2 UCN3	59 interacting genes: ABHD14A ADGRB1 AIG1 APH1A ATP1A1 ATP2C1 AUP1 B3GAT3 B4GALT2 BNIP1 CANX CD81 CH25H CMTM3 CRHR2 ERGIC3 FLRT1 FTH1 GHITM GJC2 GPR146 GPR161 HLA-A KCNJ4 KDELR1 LSS MCOLN1 MSMO1 NPC1 NSDHL OSTC PLD3 PLLP PLXDC1 PPP1R3F RTN3 RTN4 SCARB1 SDHD SELENOK SLC15A4 SLC2A1 SLC31A2 SLC37A1 SLC37A4 SLC45A4 SLC8A2 SLC9A7 SPART SYNGR2 SYT11 TMEM161A TMEM94 TSPAN7 VPS25 VTI1B YIF1B ZDHHC3 ZFAND1
Entrez ID		1395	2859
HPRD ID		03614	16003
Ensembl ID		ENSG00000106113	ENSG00000178623
Uniprot IDs		A0A090N7T4 Q13324	A8K2J1 B2RA17 Q9HC97
PDB IDs		3N93 3N95 3N96 6PB1
Enriched GO Terms of Interacting Partners?
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