COL8A2 and ATP6V0E1

Data Source:
BioGRID (two hybrid)

		COL8A2	ATP6V0E1
Description		collagen type VIII alpha 2 chain	ATPase H+ transporting V0 subunit e1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity	Protein Binding Hydrolase Activity ATPase-coupled Ion Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Angiogenesis Extracellular Matrix Organization Camera-type Eye Morphogenesis Epithelial Cell Proliferation Cell-cell Adhesion	Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases		Posterior polymorphous corneal dystrophy (PPCD) Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS		Central corneal thickness ( 32528159 29760442) Corneal structure ( 23291589) Early spontaneous preterm birth ( 31194736) Intraocular pressure ( 29617998 29785010 31959993)	Body mass index ( 27455349) PR interval ( 32439900)
Interacting Genes		18 interacting genes: ARL13B ATP6V0E1 BSND COL8A1 CREB3L1 CYB5R3 DARS2 FAM209A FNDC9 GPR152 GPX8 LMNA MUC1 PEX12 PLEKHO1 SGTA TFAM TMX2	19 interacting genes: - APOD ATP6V1E1 CDIPT COL8A2 CXCL16 EMP1 GPR25 KIR2DL3 MAL2 MS4A13 MS4A4A NAT8 OPRM1 PLN SYT15 TMEM218 TMEM254 YIPF6
Entrez ID		1296	8992
HPRD ID		08347	04894
Ensembl ID		ENSG00000171812	ENSG00000113732
Uniprot IDs		E9PP49 P25067	O15342
PDB IDs
Enriched GO Terms of Interacting Partners?
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