ATP6V0E1 and MS4A4A

Data Source:
BioGRID (two hybrid)

		ATP6V0E1	MS4A4A
Description		ATPase H+ transporting V0 subunit e1	membrane spanning 4-domains A4A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Membrane Plasma Membrane Raft
	Molecular Function	Protein Binding Hydrolase Activity ATPase-coupled Ion Transmembrane Transporter Activity Proton-transporting ATPase Activity, Rotational Mechanism	Protein Binding
	Biological Process	Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases
GWAS		Body mass index ( 27455349) PR interval ( 32439900)	Alzheimer's disease (late onset) ( 21460841) Alzheimer's disease in APOE e4- carriers ( 25778476) C-reactive protein levels ( 30388399) Cerebrospinal fluid sTREM-2 levels ( 31413141) Fibrinogen levels ( 28107422)
Interacting Genes		19 interacting genes: - APOD ATP6V1E1 CDIPT COL8A2 CXCL16 EMP1 GPR25 KIR2DL3 MAL2 MS4A13 MS4A4A NAT8 OPRM1 PLN SYT15 TMEM218 TMEM254 YIPF6	14 interacting genes: ATP6V0E1 CLDN19 CMTM7 LPAR3 MAL NRG1 PLP1 RPRM RUSF1 SEC22A SERTM1 TMEM14B TMUB2 UPK1B
Entrez ID		8992	51338
HPRD ID		04894	08408
Ensembl ID		ENSG00000113732	ENSG00000110079
Uniprot IDs		O15342	A0A384MDW1 Q4JF27 Q96JQ5
PDB IDs
Enriched GO Terms of Interacting Partners?
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