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COL8A2

Description collagen type VIII alpha 2 chain
Image No pdb structure
GO Annotations Cellular Component
  • Extracellular Region
  • Collagen Trimer
  • Basement Membrane
  • Extracellular Space
  • Endoplasmic Reticulum Lumen
  • Extracellular Matrix
  • Collagen-containing Extracellular Matrix
Molecular Function
  • Extracellular Matrix Structural Constituent
  • Extracellular Matrix Structural Constituent Conferring Tensile Strength
  • Protein-macromolecule Adaptor Activity
Biological Process
  • Angiogenesis
  • Extracellular Matrix Organization
  • Camera-type Eye Morphogenesis
  • Epithelial Cell Proliferation
  • Cell-cell Adhesion
Pathways
  • Collagen degradation
  • Collagen degradation
  • Collagen biosynthesis and modifying enzymes
  • Assembly of collagen fibrils and other multimeric structures
  • Integrin cell surface interactions
  • Collagen chain trimerization
Drugs
Diseases
  • Posterior polymorphous corneal dystrophy (PPCD)
  • Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS
  • Central corneal thickness ( 32528159 29760442)
  • Corneal structure ( 23291589)
  • Early spontaneous preterm birth ( 31194736)
  • Intraocular pressure ( 29617998 29785010 31959993)
Interacting Genes 18 interacting genes: ARL13B ATP6V0E1 BSND COL8A1 CREB3L1 CYB5R3 DARS2 FAM209A FNDC9 GPR152 GPX8 LMNA MUC1 PEX12 PLEKHO1 SGTA TFAM TMX2
Entrez ID 1296
HPRD ID 08347
Ensembl ID ENSG00000171812
Uniprot IDs E9PP49 P25067
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025