COL4A4 and SAA1

Data Source:
HPRD (in vitro)

		COL4A4	SAA1
Description		collagen type IV alpha 4 chain	serum amyloid A1
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GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength	G Protein-coupled Receptor Binding Heparin Binding
	Biological Process	Extracellular Matrix Organization Glomerular Basement Membrane Development	Activation Of MAPK Activity Positive Regulation Of Cytokine Production Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation
Drugs		TRC093
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Birth weight ( 31043758) Body mass index ( 28270201 25673413) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)
Interacting Genes		13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI	9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1
Entrez ID		1286	6288
HPRD ID		00360	00097
Ensembl ID		ENSG00000081052	ENSG00000173432
Uniprot IDs		P53420	P0DJI8
PDB IDs		5NB1	4IP8 4IP9 6MST
Enriched GO Terms of Interacting Partners?
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