CLK2 and KLHL2

Data Source:
BioGRID (two hybrid)

		CLK2	KLHL2
Description		CDC like kinase 2	kelch like family member 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Nuclear Speck	Ruffle Cytoplasm Cytosol Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Actin Binding Protein Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation	Protein Ubiquitination Post-translational Protein Modification
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Fostamatinib
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		53 interacting genes: AKT1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUZP4 MRPL4 NXF1 PRM1 PRPF38A PTPN1 RBM39 RNF8 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 SRSF3 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21	31 interacting genes: ACTC1 BCAM BYSL C20orf85 CCDC43 CDC37 CLK2 CUL3 CWC22 ELOA KEAP1 KLHL12 KLHL3 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		1196	11275
HPRD ID		04289	09311
Ensembl ID		ENSG00000176444	ENSG00000109466
Uniprot IDs		A8K7I0 B7Z8N6 P49760	B4DFZ5 E9PEX9 O95198
PDB IDs		3NR9 5UNP 6FYI 6FYK 6FYL 6KHE	2XN4 4CHB
Enriched GO Terms of Interacting Partners?
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