GABARAP and MLH1

Data Source:
BioGRID (two hybrid)

		GABARAP	MLH1
Description		GABA type A receptor-associated protein	mutL homolog 1
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Lysosome Autophagosome Smooth Endoplasmic Reticulum Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Actin Cytoskeleton Cytoplasmic Vesicle Cell Body Synapse Perinuclear Region Of Cytoplasm Sperm Midpiece	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Late Recombination Nodule Membrane Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Guanine/thymine Mispair Binding MutSalpha Complex Binding
	Biological Process	Autophagosome Assembly Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Protein Targeting Cellular Response To Nitrogen Starvation Chemical Synaptic Transmission Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Macroautophagy Autophagosome Maturation	Nuclear-transcribed MRNA Poly(A) Tail Shortening Resolution Of Meiotic Recombination Intermediates Mismatch Repair Double-strand Break Repair Via Nonhomologous End Joining Male Meiosis Chromosome Segregation Homologous Chromosome Pairing At Meiosis Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Bacterium Female Meiosis Chromosome Segregation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Metaphase I Plate Congression Meiotic Telomere Clustering Isotype Switching Negative Regulation Of Mitotic Recombination Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Oogenesis Meiotic Spindle Midzone Assembly
Pathways		Macroautophagy TBC/RABGAPs	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes Meiotic recombination
Drugs
Diseases			Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome Endometrial Cancer Ovarian cancer
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Platelet distribution width ( 32888494) Schizophrenia ( 28991256) Subjective response to lithium treatment ( 26503763)
Interacting Genes		57 interacting genes: AMBRA1 ANK2 ANK3 ATG101 ATG13 ATG3 ATG4A ATG4B ATG4C ATG4D ATG7 ATXN3 BIRC6 CUL3 DMPK DVL2 FLCN GABRG1 GABRG2 GABRG3 GPHN HDAC5 KBTBD7 KDR LMNB1 MAPK15 MEFV MIB1 MLH1 MPC1 MYBPC2 NBR1 NEDD4 NSF OPTN PCM1 PGS1 PKP4 RB1CC1 SEC62 SNX18 SQSTM1 SRPK1 SRPK2 TAX1BP1 TBC1D25 TFRC TLE5 TP53INP1 TRIM21 TRIM32 TSR2 TTN TUBB3 ULK1 ULK2 VPS28	139 interacting genes: ABCC3 ABHD16A ACER3 ACTG2 AGR2 AIFM1 ALDOA ALDOB ANXA6 AP1B1 AP2B1 APRT ARAF ASS1 ATF2 BAAT BLM BRCA1 BTBD2 C9orf152 CAB39L CAPN5 CASP3 CBY2 CCDC180 CCDC33 CCDC74B CDCA7L CDKL5 CEP126 CEP76 CKAP4 CKB CTSV CYLC2 DDX47 EEF1G EEF2 EIF2A ELP6 ENKD1 EXO1 EXOC3 FAM228A FAM50B FAM90A1 FAN1 FBXO32 FCGBP FLNB FRAT2 FRMD6 GABARAP GSTP1 HDAC6 IGKC ISY1 KPNA2 KPNA5 KPRP LEF1 LGALS4 LUC7L3 LY96 MAGEA8 MAP2K6 MBD3L1 MBD4 MLH3 MORN3 MPG MSH3 MSH4 MUC2 MYC MYL6 MYOG NANOS3 NDRG1 NELFA NFIX NME4 NT5C3B ORC4 PARP12 PARVA PCNA PER2 PIP4K2B PMS1 PMS2 PPP1R13B PPP2CB PRR5L PSMA1 PTGDS PTPN3 PTPRH RAD23B RAD9A RADX RAPGEFL1 RBM48 RSPH3 SEC61A1 SELENBP1 SERPINF1 SMAD1 SPATA8 SQSTM1 STAP2 STX17 SYF2 TASOR2 TDRD7 TFAP2D TLE5 TRIM23 TRIM29 TRMO TSGA13 TXN TXN2 U2AF1 U2AF1L5 UBOX5 VAMP8 XPA ZBED1 ZC3H11A ZER1 ZFP57 ZFP90 ZMAT5 ZNF177 ZNF212 ZNF474 ZNF559-ZNF177 ZNF774
Entrez ID		11337	4292
HPRD ID		05496	00390
Ensembl ID		ENSG00000170296	ENSG00000076242
Uniprot IDs		O95166 Q6IAW1	A0A024R2S9 P40692 Q59EG3
PDB IDs		1GNU 1KLV 1KM7 1KOT 3D32 3DOW 3WIM 4XC2 5DPS 6HB9 6HOG 6HOH 6HOJ 6HOK 6HYL 6HYM 6HYN 6HYO 7BRQ 7BRT 7BRU 7BV4	3RBN 4P7A 5U5P
Enriched GO Terms of Interacting Partners?
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