KCNE3 and SLC44A1

Data Source:
BioGRID (two hybrid)

		KCNE3	SLC44A1
Description		potassium voltage-gated channel subfamily E regulatory subunit 3	solute carrier family 44 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Vesicle Neuronal Cell Body Membrane Perikaryon Membrane Raft	Nucleoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	Choline Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Phosphatidylcholine Biosynthetic Process Choline Transport Choline Catabolic Process Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Synthesis of PC Transport of bile salts and organic acids, metal ions and amine compounds Choline catabolism
Drugs		Enflurane Promethazine Miconazole
Diseases		Brugada syndrome (BRS)
GWAS		Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)	Aluminium levels ( 26025379) Behavioral disturbance or psychiatric symptoms in prion disease ( 25897833) Glaucoma ( 30104761) Intraocular pressure ( 29617998 30591961) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 19448620) Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1	3 interacting genes: C11orf58 KCNE3 NUDT21
Entrez ID		10008	23446
HPRD ID		07256	16197
Ensembl ID		ENSG00000175538	ENSG00000070214
Uniprot IDs		Q6IAE6 Q9Y6H6	A0A024R151 Q8WWI5
PDB IDs		2NDJ 6V00 6V01
Enriched GO Terms of Interacting Partners?
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