DBF4 and ORC2

Data Source:
HPRD (two hybrid, in vitro)

		DBF4	ORC2
Description		DBF4 zinc finger	origin recognition complex subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex	Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity	DNA Replication Origin Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		18 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6	28 interacting genes: CDC45 CDC5L CDC6 CDK2 CDT1 CTNNA3 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RAD18 RIPPLY3 RPA1 RPA2 XRCC5
Entrez ID		10926	4999
HPRD ID		10371	03112
Ensembl ID		ENSG00000006634	ENSG00000115942
Uniprot IDs		B4DXK0 B7Z8C6 Q9UBU7	A0A024R411 Q13416
PDB IDs		4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8	5C8H 5UJ8 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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