SUB1 and CBX5

Data Source:
BioGRID (pull down)

		SUB1	CBX5
Description		SUB1 regulator of transcription	chromobox 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Extracellular Exosome	Histone Deacetylase Complex Kinetochore Chromosome, Telomeric Region Heterochromatin Nucleus Nuclear Envelope Nucleoplasm Pericentric Heterochromatin Nucleolus Chromocenter PML Body Transcription Repressor Complex Protein-containing Complex Histone Methyltransferase Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Identical Protein Binding	Chromatin Binding Protein Binding Protein-macromolecule Adaptor Activity Methylated Histone Binding Identical Protein Binding Histone Deacetylase Binding Ribonucleoprotein Complex Binding Protein-containing Complex Binding Repressing Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA Metabolic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter SMAD Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways			SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production
Drugs			Copper
Diseases
GWAS		Metabolite levels ( 23823483) PR interval ( 32439900)	Adult body size ( 32376654) Alcohol consumption ( 31358974) Hip circumference ( 28552196) Mean platelet volume ( 22139419) Meat-related diet ( 32066663) Platelet count ( 32888494) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ADAP1 APP CBX5 CSNK2A1 CSTF2 EP300 GTF2A1L HNF4A HSF1 OTUD5 PCNA POLR2A POLR2B POU2AF1 PSIP1 RCOR1 REST SDCBP SP1 TAF1 TBP TP53	59 interacting genes: ARHGDIA ARL5A BAP1 BARD1 BCL11B BRCA1 CBX1 CBX3 CHAF1A DNMT3B DSN1 ELOA2 ELOC ENO1 FSHR GOLGA8EP H1-4 H1-5 H2AW H2BU1 H3-4 H3C15 H4-16 HDAC4 HDAC5 HDAC9 HECW2 INCENP LAP3 LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSD3 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 TAF4 TRIM24 TRIM28 UBE2A UBE2B VPS28 XRCC6 XRN1 ZNF280C ZNF280D
Entrez ID		10923	23468
HPRD ID		02737	05131
Ensembl ID		ENSG00000113387	ENSG00000094916
Uniprot IDs		P53999 Q6IBA2	P45973 V9HWG0
PDB IDs		1PCF 2C62 2PHE 4USG 6YCS	3FDT 3I3C
Enriched GO Terms of Interacting Partners?
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