GRAP and EPOR

Data Source:
HPRD (in vivo, in vitro)

		GRAP	EPOR
Description		GRB2 related adaptor protein	erythropoietin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Presynapse	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	Protein Binding	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization
Pathways		Signaling by SCF-KIT	Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Copper levels ( 26025379)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		17 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 RBPMS REL SHC1 SOS1 TOX TRIM21	39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL
Entrez ID		10750	2057
HPRD ID		05062	00587
Ensembl ID		ENSG00000154016	ENSG00000187266
Uniprot IDs		I3L2P9 Q13588	P19235
PDB IDs			1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL
Enriched GO Terms of Interacting Partners?
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