EPOR and VAV1

Data Source:
HPRD (in vitro)

		EPOR	VAV1
Description		erythropoietin receptor	vav guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Metal Ion Binding Phosphorylation-dependent Protein Binding
	Biological Process	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization	Immune Response G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Cytokine-mediated Signaling Pathway Platelet Activation T Cell Differentiation Neutrophil Chemotaxis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Reactive Oxygen Species Metabolic Process
Pathways		Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Blood protein levels ( 30072576) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494 27863252) Monocyte count ( 32888494) Periodontitis ( 23459936) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252)
Interacting Genes		39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL	79 interacting genes: ABL1 ACTA1 AOC3 AR ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 ERBB4 EZH2 FGFR1 FYN GAB1 GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX
Entrez ID		2057	7409
HPRD ID		00587	01284
Ensembl ID		ENSG00000187266	ENSG00000141968
Uniprot IDs		P19235	A0A0A0MR07 B2R8B5 P15498 Q96D37
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL	2CRH 2LCT 2MC1 2ROR 3BJI 3KY9 6NEW 6NF1 6NFA
Enriched GO Terms of Interacting Partners?
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