EPOR and KLK3

Data Source:
HPRD (in vitro, in vivo)

		EPOR	KLK3
Description		erythropoietin receptor	kallikrein related peptidase 3
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
	Biological Process	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization	Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation Cellular Protein Metabolic Process
Pathways		Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta	Mifepristone Cyproterone acetate Gallium Ga-68 gozetotide
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 31562322 26034056 24753544) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 25434496 23269536 28139693 24919509) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)
Interacting Genes		39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL	14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI
Entrez ID		2057	354
HPRD ID		00587	01461
Ensembl ID		ENSG00000187266	ENSG00000142515
Uniprot IDs		P19235	P07288 Q546G3
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL	1PFA 2PSA 2ZCH 2ZCK 2ZCL 3QUM
Enriched GO Terms of Interacting Partners?
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