RAI1 and LZTR1

Data Source:
BioGRID (two hybrid)

		RAI1	LZTR1
Description		retinoic acid induced 1	leucine zipper like transcription regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Small GTPase Binding
	Biological Process	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription, DNA-templated	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways		Circadian Clock
Drugs
Diseases		Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		Body mass index ( 28892062) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hip circumference ( 25673412) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 27863252) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458 30297969)
Interacting Genes		17 interacting genes: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ZNF496	55 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RIT1 RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		10743	8216
HPRD ID		07406	08992
Ensembl ID		ENSG00000108557	ENSG00000099949
Uniprot IDs		Q7Z5J4	A0A384NL67 Q8N653
PDB IDs
Enriched GO Terms of Interacting Partners?
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