LZTR1 and E2F8

Data Source:
BioGRID (two hybrid)

		LZTR1	E2F8
Description		leucine zipper like transcription regulator 1	E2F transcription factor 8
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane	Chromatin Nucleoplasm Nucleolus Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Small GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Placenta Development Sprouting Angiogenesis Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Population Proliferation Negative Regulation Of Cytokinesis Positive Regulation Of DNA Endoreduplication Cell Cycle Comprising Mitosis Without Cytokinesis Positive Regulation Of Transcription By RNA Polymerase II Trophoblast Giant Cell Differentiation Chorionic Trophoblast Cell Differentiation Hepatocyte Differentiation
Pathways			TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Drugs
Diseases
GWAS			Mean reticulocyte volume ( 32888494)
Interacting Genes		55 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 GABARAPL2 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RIT1 RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3	8 interacting genes: APP EWSR1 FHL3 LZTR1 MEOX2 STUB1 TFCP2 ZDHHC17
Entrez ID		8216	79733
HPRD ID		08992	10981
Ensembl ID		ENSG00000099949	ENSG00000129173
Uniprot IDs		A0A384NL67 Q8N653	A0AVK6
PDB IDs			4YO2
Enriched GO Terms of Interacting Partners?
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