CTCF and MT-ND4

Data Source:
BioGRID (two hybrid)

		CTCF	MT-ND4
Description		CCCTC-binding factor	NADH dehydrogenase subunit 4
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane Respiratory Chain Complex I
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding	NADH Dehydrogenase Activity NADH Dehydrogenase (ubiquinone) Activity Ubiquinone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription By RNA Polymerase II Chromosome Segregation Negative Regulation Of Cell Population Proliferation Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Nucleosome Positioning Regulation Of Histone Methylation Regulation Of Histone Acetylation Regulation Of Gene Expression, Epigenetic Regulation Of Molecular Function, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region Genetic Imprinting	Response To Hypoxia In Utero Embryonic Development Mitochondrial Electron Transport, NADH To Ubiquinone Aging Aerobic Respiration Electron Transport Coupled Proton Transport Cerebellum Development Mitochondrial Respiratory Chain Complex I Assembly Response To Nicotine Response To Ethanol
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS		Elevated fasting plasma glucose ( 30004843) Eosinophil percentage of white cells ( 32888494) HDL cholesterol ( 19060911) Hemoglobin levels ( 32327693) Refractive error ( 32231278)
Interacting Genes		21 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 SUZ12 THRB TRAF2 TRB YBX1 ZMYM4 ZMYM6	7 interacting genes: ABHD16A APC ATM CTCF GRB2 LIG4 NKX3-1
Entrez ID		10664	4538
HPRD ID		05005	08954
Ensembl ID		ENSG00000102974	ENSG00000198886
Uniprot IDs		A0A2R8YFL0 P49711	A0A1X7RBN5 H9EC08 P03905
PDB IDs		1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL 6QNX	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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