POLR3F and SUV39H2

Data Source:
BioGRID (two hybrid)

		POLR3F	SUV39H2
Description		RNA polymerase III subunit F	suppressor of variegation 3-9 homolog 2
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GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase III Complex Cytosol	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm
	Molecular Function	Double-stranded DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) S-adenosyl-L-methionine Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase III Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Cell Cycle Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		15 interacting genes: ATPAF2 BDP1 BRF1 ERG28 GTF3C4 KAT5 LRIF1 PRPF4B RIN3 STC2 SUV39H2 TBP TNS2 UBE2G2 WDR89	41 interacting genes: AKAP9 APPL2 AR BLZF1 C8orf74 CBX7 CDCA4 CEP70 CFAP100 CGGBP1 EWSR1 FAM20C GOLGA6L9 GSTCD ID2 KCTD17 KLF3 KLHDC4 LCA5L LNX1 LRIF1 MAGEA11 MCM3AP MRFAP1 MTF2 MYL12A NME4 ODAD3 PHF19 PNMA1 POLR3F RAB3IP RASSF1 SHC1 SMAD5 SNF8 UBE2V2 WIZ ZNF212 ZNF557 ZNF57
Entrez ID		10621	79723
HPRD ID		15156	07580
Ensembl ID		ENSG00000132664	ENSG00000152455
Uniprot IDs		Q05DB8 Q9H1D9	Q9H5I1
PDB IDs		2DK5 2YU3	2R3A 6P0R
Enriched GO Terms of Interacting Partners?
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