DRAP1 and POLE3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DRAP1	POLE3
Description		DR1 associated protein 1	DNA polymerase epsilon 3, accessory subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Negative Cofactor 2 Complex RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex CHRAC
	Molecular Function	Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Identical Protein Binding Protein Heterodimerization Activity	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Telomere Maintenance Via Semi-conservative Replication Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process
Pathways		Signaling by NODAL Signaling by Activin	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil percentage of granulocytes ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		31 interacting genes: APP ARHGEF10L CDKN2C DNAJB11 DR1 FBXO7 FEZ1 FEZ2 FOXH1 GTF2B LMO2 LNX1 LNX2 MCRS1 MORF4L1 NCK2 NFYB PICK1 PIK3R3 PLEKHF2 POLE3 RPL9 SDCBP SRPK2 TAF9 TAF9B TBP TK1 TNFRSF14 TTF2 ZEB1	7 interacting genes: APP BAZ1A CHRAC1 DR1 DRAP1 POLE4 SMARCA5
Entrez ID		10589	54107
HPRD ID		03796	06274
Ensembl ID		ENSG00000175550	ENSG00000148229
Uniprot IDs		Q14919	A0A024R829 Q9NRF9
PDB IDs		1JFI
Enriched GO Terms of Interacting Partners?
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