POLE3 and BAZ1A

Data Source:
BioGRID (genetic interference, pull down)

		POLE3	BAZ1A
Description		DNA polymerase epsilon 3, accessory subunit	bromodomain adjacent to zinc finger domain 1A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Epsilon DNA Polymerase Complex CHRAC	Nuclear Chromosome CHRAC ACF Complex
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	Histone Acetyltransferase Activity Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Telomere Maintenance Via Semi-conservative Replication Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process	DNA-dependent DNA Replication Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Histone Acetylation
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine
Diseases
GWAS			Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Non-small cell lung cancer ( 31326317) Red blood cell count ( 32888494) Response to bupropion in depression ( 27622933) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		7 interacting genes: APP BAZ1A CHRAC1 DR1 DRAP1 POLE4 SMARCA5	11 interacting genes: CHRAC1 MTNR1A POLE3 SATB1 SMAD2 SMAD9 SMARCA5 SRPK2 SUMO2 XRCC5 XRCC6
Entrez ID		54107	11177
HPRD ID		06274	12034
Ensembl ID		ENSG00000148229	ENSG00000198604
Uniprot IDs		A0A024R829 Q9NRF9	Q9NRL2
PDB IDs			5UIY
Enriched GO Terms of Interacting Partners?
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