YAF2 and MARK1

Data Source:
BioGRID (two hybrid)

		YAF2	MARK1
Description		YY1 associated factor 2	microtubule affinity regulating kinase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite
	Molecular Function	DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization
Pathways		RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Transcriptional Regulation by E2F6
Drugs			Fostamatinib
Diseases
GWAS		Refractive error ( 32231278)	Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)
Interacting Genes		29 interacting genes: ANP32B CAVIN1 CD300LF DNAAF6 EAF1 GABPB1 IFT57 INO80B LGALS7 LGALS7B MAPRE3 MARK1 MYC MYCN NEDD8 NUTF2 PCDH17 POLR3GL PPP1R11 RING1 RNF2 SETBP1 SPANXN2 SPANXN3 TLK1 UBC XAGE1B YY1 ZFP42	10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2
Entrez ID		10138	4139
HPRD ID		09606	07353
Ensembl ID		ENSG00000015153	ENSG00000116141
Uniprot IDs		B4DJQ9 G3V212 Q8IY57	A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4
PDB IDs		2D9G	2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?
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