MARK1 and MAP4

Data Source:
HPRD (in vitro)

		MARK1	MAP4
Description		microtubule affinity regulating kinase 1	microtubule associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Microtubule Cytoskeleton Axon Neuron Projection Mitotic Spindle
	Molecular Function	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding Structural Molecule Activity Protein Binding Microtubule Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Neuron Projection Development Microtubule Sliding Establishment Of Spindle Orientation Cell Division Negative Regulation Of Non-motile Cilium Assembly
Pathways
Drugs		Fostamatinib	Paclitaxel Docetaxel Artenimol
Diseases
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)	Blood pressure ( 21909110) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 27841878 28739976 27618452) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean arterial pressure ( 27618448) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 28739976 27618452 30578418)
Interacting Genes		10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2	23 interacting genes: CCNB1 CDC42 CDK1 CLASP1 ENO2 ERBIN GSK3B IL7R LDLR MARK1 MARK4 NOP58 NR1I3 POT1 RXRB RXRG SNTA1 SRPK2 STRBP SUMO2 TERF1 TUBB UBC
Entrez ID		4139	4134
HPRD ID		07353	01141
Ensembl ID		ENSG00000116141	ENSG00000047849
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	P27816
PDB IDs		2HAK 3OSE 6C9D
Enriched GO Terms of Interacting Partners?
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