PPP5C and CDC16

Data Source:
HPRD (in vitro, two hybrid)

		PPP5C	CDC16
Description		protein phosphatase 5 catalytic subunit	cell division cycle 16
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Protein-containing Complex Perikaryon Intracellular Membrane-bounded Organelle Chaperone Complex Proximal Dendrite	Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	G-protein Alpha-subunit Binding RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding ATP Binding Microtubule Binding Lipid Binding Phosphatase Activity Identical Protein Binding ADP Binding Protein-containing Complex Binding Metal Ion Binding Tau Protein Binding Hsp90 Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding
	Biological Process	MAPK Cascade Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation DNA Repair Transcription, DNA-templated Protein Dephosphorylation Response To Lead Ion Histone Dephosphorylation Peptidyl-threonine Dephosphorylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Peptidyl-serine Dephosphorylation Cellular Response To Hydrogen Peroxide Cellular Response To Cadmium Ion Negative Regulation Of Neuron Death Response To Arachidonic Acid Positive Regulation Of Glucocorticoid Receptor Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		ATP
Diseases
GWAS		Basophil percentage of white cells ( 27863252) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neuroticism ( 29255261) Response to antidepressants in depression ( 29998114) Triglyceride levels ( 32203549)	Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Prudent dietary pattern ( 28644415) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		26 interacting genes: APP CDC16 CDC27 CDC37 CDK20 CHORDC1 CPNE1 CPNE2 CPNE4 CRY2 CSE1L CSNK1D DISC1 EGFR ESR2 GNA12 GNA13 HSP90AA1 HTR2A HUWE1 MAP3K5 MAP3K7 MAPT PPP2R1A PPP2R3A VHL	24 interacting genes: ANAPC10 ANAPC11 ANAPC7 BUB1B C11orf49 CDC20 CDC23 CDC26 CDC27 DAB2 DNAJA1 FBXO5 FTH1 HINT1 LINC00839 MAD2L1 MAPK9 MTNR1B PPP5C SKIL SMAD2 SMAD3 UBE2S XRCC5
Entrez ID		5536	8881
HPRD ID		02805	04587
Ensembl ID		ENSG00000011485	ENSG00000130177
Uniprot IDs		A0A024R0Q7 P53041	A0A024RDZ2 A0A3B3ISD2 B2RCW0 Q13042
PDB IDs		1A17 1S95 1WAO 2BUG 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H68 3H69 4ZVZ 4ZX2 5HPE 5UI1 5WG8	3HYM 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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