TOM1 and PTBP2

Data Source:
BioGRID (two hybrid)

		TOM1	PTBP2
Description		target of myb1 membrane trafficking protein	polypyrimidine tract binding protein 2
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body
	Molecular Function	Protein Binding Clathrin Binding	RNA Binding MRNA Binding
	Biological Process	Intracellular Protein Transport Endocytosis Signal Transduction Protein Transport Endosomal Transport Neutrophil Degranulation	MRNA Splice Site Selection Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398 30944420) Waist circumference ( 25673412)
Interacting Genes		21 interacting genes: APP CLTC DAZAP2 EEA1 ILVBL LITAF LRRC20 MAP3K1 MYO6 NAA11 NEDD4 PILRA PTBP2 RPS27 SMURF1 SSBP2 TOLLIP UBC UBE2D1 ZFYVE16 ZNF512B	19 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA TOM1
Entrez ID		10043	58155
HPRD ID		05265	12233
Ensembl ID		ENSG00000100284	ENSG00000117569
Uniprot IDs		B3KUF5 O60784	A0A6Q8PFE6 B4DSS8 B4DSU5 Q9UKA9
PDB IDs		1ELK 1WRD 2N2N 2N9D 6J56	2CQ1 2MJU 4CQ1
Enriched GO Terms of Interacting Partners?
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