PTBP2 and HNRNPC

Data Source:
BioGRID (two hybrid)

		PTBP2	HNRNPC
Description		polypyrimidine tract binding protein 2	heterogeneous nuclear ribonucleoprotein C
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GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding MRNA Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Binding
	Biological Process	MRNA Splice Site Selection Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Splicing RNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase ATP-dependent Chromatin Remodeling 3'-UTR-mediated MRNA Stabilization
Pathways			SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS		Adult body size ( 32376654) Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 32239398 30944420) Waist circumference ( 25673412)	Bipolar disorder ( 31043756 21738484) Height ( 31562340)
Interacting Genes		19 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PUF60 QKI RBM10 RBM4 RBPMS2 SNRPA TOM1	58 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 BTRC CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 EPS8 ERG ESR1 FAS FXR2 GRB2 HNRNPCL1 HNRNPCL2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MEOX2 PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALY RALYL RBM41 RBPMS2 RNF4 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I YWHAE YWHAQ ZFYVE26 ZNF581
Entrez ID		58155	3183
HPRD ID		12233	01243
Ensembl ID		ENSG00000117569	ENSG00000092199
Uniprot IDs		A0A6Q8PFE6 B4DSS8 B4DSU5 Q9UKA9	P07910
PDB IDs		2CQ1 2MJU 4CQ1	1TXP 1WF2 2MXY 2MZ1 3LN4
Enriched GO Terms of Interacting Partners?
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