GIT2 and PXN

Number of citations of the paper that reports this interaction (PubMedID 16628223)
36

Data Source:
HPRD (in vivo, in vitro)

		GIT2	PXN
Description		GIT ArfGAP 2	paxillin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Stress Fiber Cytosol Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Transcription Coregulator Activity Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Catalytic Activity	Regulation Of Transcription, DNA-templated Cell Adhesion Cell-matrix Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)	Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	90 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK IMPDH2 ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PCM1 PDPK1 PKD1 PLEKHH2 PLEKHN1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SCARB1 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN YES1
Entrez ID		9815	5829
HPRD ID		09779	03937
Ensembl ID		ENSG00000139436	ENSG00000089159
Uniprot IDs		F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58	A0A140VJQ8 P49023
PDB IDs			1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N
Enriched GO Terms of Interacting Partners?
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