GIT2 and PCLO

Number of citations of the paper that reports this interaction (PubMedID 12473661)
56

Data Source:
BioGRID (two hybrid)

		GIT2	PCLO
Description		GIT ArfGAP 2	piccolo presynaptic cytomatrix protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Cytoskeleton Postsynaptic Density Axon Synapse Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Catalytic Activity	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Synaptic Vesicle Clustering Presynapse To Nucleus Signaling Pathway Presynaptic Active Zone Assembly
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Energy expenditure (24h) ( 28476931) Grapefruit juice consumption ( 31046077) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 21621269 28540843 20351715) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 33169155)
Interacting Genes		48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	4 interacting genes: ERC2 GIT1 GIT2 PCAT1
Entrez ID		9815	27445
HPRD ID		09779	16078
Ensembl ID		ENSG00000139436	ENSG00000186472
Uniprot IDs		F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58	Q9Y6V0
PDB IDs			1UJD
Enriched GO Terms of Interacting Partners?
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