GIT2 and GET4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GIT2	GET4
Description		GIT ArfGAP 2	guided entry of tail-anchored proteins factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol BAT3 Complex
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Protein Binding Chaperone Binding
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Catalytic Activity	Protein Insertion Into ER Membrane Cytoplasmic Sequestering Of Protein Tail-anchored Membrane Protein Insertion Into ER Membrane Maintenance Of Unfolded Protein Involved In ERAD Pathway
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)	PR interval ( 32439900)
Interacting Genes		48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	30 interacting genes: AKT1 ATP5PD BAG6 C1orf109 CAPNS1 CDKN1A CEP126 DNAAF5 DUSP21 EEF1G ENKD1 FBN1 FLYWCH2 GET3 GIT2 KAT5 KIFC2 KRTAP9-3 NUP85 PLK1 PRKAB2 PRKCSH PTMS SDCBP SEC61B SNCAIP SOD2 TMEM256 TTR UBAC2
Entrez ID		9815	51608
HPRD ID		09779	12909
Ensembl ID		ENSG00000139436	ENSG00000239857
Uniprot IDs		F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58	Q7L5D6
PDB IDs			6AU8
Enriched GO Terms of Interacting Partners?
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