PXN and PTPN11

  • Number of citations of the paper that reports this interaction (PubMedID 10655584)
  • 181
  • Data Source:
  • HPRD (in vitro, in vivo)

PXN

PTPN11

Description paxillin protein tyrosine phosphatase non-receptor type 11
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Bipolar disorder ( 31043756)
  • Left ventricle wall thickness ( 33495596)
  • Left ventricular end-systolic volume ( 33495596)
  • Left ventricular mass to end-diastolic volume ratio ( 33495596)
  • Mean spheric corpuscular volume ( 32888494)
  • Platelet count ( 29403010)
  • Alcohol consumption (max-drinks) ( 29460428)
  • Alcohol dependence symptom count ( 29460428)
  • Apolipoprotein A1 levels ( 32203549)
  • Blood pressure ( 21572416)
  • Body mass index ( 26426971)
  • Diastolic blood pressure ( 26390057)
  • Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Glycated hemoglobin levels ( 34059833)
  • HDL cholesterol levels ( 32203549)
  • Hematological parameters ( 19820697)
  • Hip circumference adjusted for BMI ( 34021172)
  • Hypothyroidism ( 22493691)
  • Low HDL-cholesterol levels ( 31006500)
  • Mean arterial pressure ( 27618448)
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401)
  • Medication use (beta blocking agents) ( 31015401)
  • Medication use (diuretics) ( 31015401)
  • Medication use (thyroid preparations) ( 31015401)
  • Multiple sclerosis ( 31604244)
  • Peripheral artery disease ( 31285632)
  • Platelet count ( 22139419 32888494)
  • Reaction time ( 29844566)
  • Response to alcohol consumption (flushing response) ( 29460428)
  • Retinal vascular caliber ( 21060863)
  • Rheumatoid arthritis ( 30423114 24390342)
  • Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
  • Systolic blood pressure ( 26390057 30578418)
  • Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
  • Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
  • Tetralogy of Fallot ( 23297363)
  • Type 1 diabetes ( 17554300)
  • Urate levels ( 23263486)
  • Waist-to-hip ratio adjusted for BMI ( 34054925)
Interacting Genes 90 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK IMPDH2 ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PCM1 PDPK1 PKD1 PLEKHH2 PLEKHN1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SCARB1 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN YES1 173 interacting genes: AATK ACTN4 AKT1 AR ARHGAP1 AXL BCR BDKRB2 BEX1 BEX2 BLZF1 BRAP BTLA CALR CAT CAV1 CBL CCKBR CD33 CDH5 CEACAM1 CHUK CRKL CSF2RB CSF3R CTDSP1 CTLA4 CXCR4 DAB1 DDR1 DMRTC1 EGFR EPHA1 EPHA2 EPOR ERBB2 ERBB3 ERBB4 FAM71E1 FBXW7 FCGR1B FCGR2B FCRL3 FGFR2 FGFR4 FLT1 FLT3 FLT4 FRS2 FRS3 FYN GAB1 GAB2 GAB3 GHR GMNN GOLGA2 GRB2 GRIN2B GTF2A2 HIP1R HNRNPU HSP90B1 HSPA5 HSPA9 HSPD1 IFNAR1 IFNGR1 IGF1R IL4R IL6ST ILK INPP5D INSR IRS1 IRS2 IRS4 JAK1 JAK2 KDR KIR2DL5A KIT KLRC1 LAIR1 LCK LEPR LIFR LILRB4 LINC01558 LINC02907 LNX1 LRP1 MAP3K4 MAP3K5 MAPK3 MAPT MET MPIG6B MPL MPZL1 MS4A2 MVK MVP NCOR2 NEB NEDD9 NOX4 NRG3 NSUN5 NSUN5P2 NTRK1 NTRK2 ORMDL3 P2RX7 PAG1 PDGFRA PDGFRB PECAM1 PIK3CA PIK3CG PIK3R1 PILRA PILRB PLCG1 PNCK POU2AF1 PRKCA PRKCB PRKCH PRLR PTK2 PTK2B PTK7 PTPN6 PXN RANGRF RCOR3 RET ROR2 ROS1 RPIA SELE SERF2 SERPINF1 SHC1 SIGLEC11 SIGLEC12 SIGLEC7 SIRPA SIT1 SLAMF1 SLAMF6 SLC38A1 SLN SOCS3 SOS1 SPRY2 SRC SRSF10 STAT1 STAT3 STAT5A STAT5B SYNCRIP TEK TIE1 TLK1 TNFRSF1A TREML1 TRIM32 TRMT2B TSC2 TXNIP
Entrez ID 5829 5781
HPRD ID 03937 01470
Ensembl ID ENSG00000089159 ENSG00000179295
Uniprot IDs A0A140VJQ8 P49023 Q06124
PDB IDs 1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 2SHP 3B7O 3MOW 3O5X 3TKZ 3TL0 3ZM0 3ZM1 3ZM2 3ZM3 4DGP 4DGX 4GWF 4H1O 4H34 4JE4 4JEG 4JMG 4NWF 4NWG 4OHD 4OHE 4OHH 4OHI 4OHL 4PVG 4QSY 4RDD 5BK8 5DF6 5EHP 5EHR 5I6V 5IBM 5IBS 5X7B 5X94 5XZR 6ATD 6BMR 6BMU 6BMV 6BMW 6BMX 6BMY 6BN5 6CMP 6CMQ 6CMR 6CMS 6CRF 6CRG 6IHZ 6MD7 6MD9 6MDA 6MDB 6MDC 6MDD 6R5G 7JVM 7JVN
Enriched GO Terms of Interacting Partners?
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