ULK2 and SYNGAP1

Number of citations of the paper that reports this interaction (PubMedID 15014045)
79

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		ULK2	SYNGAP1
Description		unc-51 like autophagy activating kinase 2	synaptic Ras GTPase activating protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle Membrane Phagophore Assembly Site Membrane	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Autophagy Signal Transduction Peptidyl-serine Phosphorylation Piecemeal Microautophagy Of The Nucleus Response To Starvation Late Nucleophagy Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Positive Regulation By Symbiont Of Host Autophagy	Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Regulation Of GTPase Activity Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure
Pathways			Regulation of RAS by GAPs
Drugs		Fostamatinib
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		16 interacting genes: ATG14 DIXDC1 DUXAP9 EEF1B2 GABARAP GABARAPL2 LNX1 LUC7L2 NASP POLA2 RAI1 SETDB1 SQSTM1 SYNGAP1 TNPO1 ZNF32	29 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX
Entrez ID		9706	8831
HPRD ID		10556	16018
Ensembl ID		ENSG00000083290	ENSG00000197283
Uniprot IDs		Q8IYT8	A0A1U9X8L0 B7ZCA0 Q96PV0
PDB IDs		6QAT 6QAU 6QAV 6YID
Enriched GO Terms of Interacting Partners?
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