SYNGAP1 and DLGAP4

Number of citations of the paper that reports this interaction (PubMedID 9581761)
170

Data Source:
HPRD (two hybrid, in vivo)

		SYNGAP1	DLGAP4
Description		synaptic Ras GTPase activating protein 1	DLG associated protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse	Plasma Membrane Neuromuscular Junction Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Binding Molecular Adaptor Activity
	Biological Process	Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Regulation Of GTPase Activity Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure	Signaling Regulation Of Postsynaptic Neurotransmitter Receptor Activity
Pathways		Regulation of RAS by GAPs	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)	Low density lipoprotein cholesterol levels ( 32154731) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		29 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX	33 interacting genes: ABI2 ALDH16A1 ATPAF2 BIN1 DLG1 DLG3 DLG4 EXOC4 FHL3 FHL5 FKBP6 FYN GRIN1 GRIN2D MAGEA6 MPP7 MTUS2 NCK1 NCK2 NKX2-2 PALS1 PLP2 PPP1R1B SH3GL2 SH3RF1 SHANK2 SHANK3 SLC9A3R1 SLC9A3R2 SORBS2 SYNGAP1 UBASH3A UBC
Entrez ID		8831	22839
HPRD ID		16018	16826
Ensembl ID		ENSG00000197283	ENSG00000080845
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0	A0A0B4J2C2 Q9Y2H0
PDB IDs
Enriched GO Terms of Interacting Partners?
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