SYNGAP1 and GRIN2D

Number of citations of the paper that reports this interaction (PubMedID 10862698)
367

Data Source:
HPRD (in vivo)

		SYNGAP1	GRIN2D
Description		synaptic Ras GTPase activating protein 1	glutamate ionotropic receptor NMDA type subunit 2D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Postsynaptic Density Membrane
	Molecular Function	GTPase Activator Activity Protein Binding SH3 Domain Binding	Ionotropic Glutamate Receptor Activity NMDA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity
	Biological Process	Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Regulation Of GTPase Activity Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure	Startle Response Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission
Pathways		Regulation of RAS by GAPs	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		29 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 EFHC1 GRIN1 GRIN2B GRIN2D GUCD1 HSF2BP KDR MGAT5B MID2 MKRN3 MPDZ NCK2 NTAQ1 OSTF1 PDGFRB SHANK3 SPAG8 SUOX TLX3 TRIM27 TRIP6 TSSK3 ULK1 ULK2 VENTX	33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		8831	2906
HPRD ID		16018	04095
Ensembl ID		ENSG00000197283	ENSG00000105464
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0	O15399 Q59G17
PDB IDs
Enriched GO Terms of Interacting Partners?
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