PRDM6 and COX5B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRDM6	COX5B
Description		PR/SET domain 6	cytochrome c oxidase subunit 5B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex IV
	Molecular Function	Protein Binding Histone Methyltransferase Activity Identical Protein Binding Metal Ion Binding	Cytochrome-c Oxidase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Histone Methylation Neurogenesis Negative Regulation Of Smooth Muscle Cell Differentiation	Mitochondrial Electron Transport, Cytochrome C To Oxygen Respiratory Gaseous Exchange By Respiratory System Proton Transmembrane Transport
Pathways			TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1
Drugs			Cholic Acid N-Formylmethionine
Diseases
GWAS		Body mass index ( 28892062) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Male-pattern baldness ( 28196072) Mammographic density (dense area) ( 25342443) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Percent mammographic density ( 25342443) Pulse pressure ( 27841878 27618447) QRS duration ( 25035420) Systolic blood pressure ( 26390057 27841878 27618447 30578418)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		70 interacting genes: ABI2 AGXT AHCYL1 ANKS1A AQP1 ARID5A ATPAF2 ATXN7L2 BAG3 BANF2 BANP C1orf109 CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM214B FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A STK16 TCAF1 TEKT4 TLE5 TRIM14 TRMT12 TSGA10 TSGA10IP TSSK3 TTC23 UBASH3A USP54 ZFYVE26	36 interacting genes: AR ARID5A BHLHE40 CDC42EP2 CDR2 CDR2L DOK3 FAM228A FLOT1 GOLGA2 IHO1 KRT15 KRT27 KRT31 KRT33B LSM4 MCCD1 MID2 NPHP1 NUDT5 OIP5 PLEKHF2 PNMA1 PPP1R32 PRDM6 PRKAR1B PRR22 RBM48 SLAIN1 TASOR2 TEX12 TFIP11 TRAF1 TRIM23 TRIM27 VPS28
Entrez ID		93166	1329
HPRD ID		19698	00467
Ensembl ID		ENSG00000061455	ENSG00000135940
Uniprot IDs		Q9NQX0	A0A384NL93 P10606
PDB IDs			5Z62
Enriched GO Terms of Interacting Partners?
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