MKNK1 and PABPC4

		MKNK1	PABPC4
Description		MAPK interacting serine/threonine kinase 1	poly(A) binding protein cytoplasmic 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development
Pathways		Spry regulation of FGF signaling
Drugs		Fostamatinib
Diseases
GWAS		Schizophrenia ( 26198764) Triglyceride levels ( 31170924)	Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Walking pace ( 33128006)
Interacting Genes		27 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PABPC4 PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	26 interacting genes: CDC42 DUX4 EEF1A1 FOXD3 GDF9 HAP1 HCRTR1 IL7R LUC7L2 MED31 MKNK1 MTF1 NMNAT1 OGT PHLDA1 PRKCG RIF1 S100A8 SETDB1 SMAD9 SREK1 SRPK2 UBC VPS26B XRN1 ZNF655
Entrez ID		8569	8761
HPRD ID		09468	04557
Ensembl ID		ENSG00000079277	ENSG00000090621
Uniprot IDs		A8K341 Q7Z319 Q9BUB5	Q13310
PDB IDs		2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?