MKNK1 and DNAJC7

Number of citations of the paper that reports this interaction (PubMedID 20936779)
88

Data Source:
BioGRID (two hybrid)

		MKNK1	DNAJC7
Description		MAPK interacting serine/threonine kinase 1	DnaJ heat shock protein family (Hsp40) member C7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	ATPase Activator Activity Protein Binding Heat Shock Protein Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Protein Folding Regulation Of Catalytic Activity Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat
Pathways		Spry regulation of FGF signaling	Regulation of HSF1-mediated heat shock response
Drugs		Fostamatinib
Diseases
GWAS		Schizophrenia ( 26198764) Triglyceride levels ( 31170924)	Major depressive disorder x sex interaction ( 34099189)
Interacting Genes		27 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PABPC4 PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	13 interacting genes: DISC1 HSP90AA1 HUS1 MKNK1 NF1 OGT RAD1 RAD9A SMAD2 SMAD9 SMURF1 TP53 UBE4B
Entrez ID		8569	7266
HPRD ID		09468	07046
Ensembl ID		ENSG00000079277	ENSG00000168259
Uniprot IDs		A8K341 Q7Z319 Q9BUB5	Q99615
PDB IDs		2HW6 2Y9Q 5WVD
Enriched GO Terms of Interacting Partners?
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