MKNK1 and TNIP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		MKNK1	TNIP2
Description		MAPK interacting serine/threonine kinase 1	TNFAIP3 interacting protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Regulation Of Translation Protein Phosphorylation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Spry regulation of FGF signaling	MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
Drugs		Fostamatinib
Diseases
GWAS		Schizophrenia ( 26198764) Triglyceride levels ( 31170924)	Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 33536424)
Interacting Genes		27 interacting genes: APP ATXN3 CREBBP CREM DDAH2 DNAJC7 EIF4E EIF4G1 EIF4G2 EIF4G3 FANCA HGS HIPK2 HSP90AB1 MAPK1 MAPK14 MAPK3 MBP PABPC4 PAK2 PHAX PLA2G4A PRKDC RCN3 SPRY2 TNIP2 UBE2D1	29 interacting genes: APP CACNA1C CDKN1A CLK1 EP300 FBXO25 FLNA FXR2 GCH1 IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NDUFB9 NFKB1 NFKB2 PSMD9 REL RELA SHANK3 SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC
Entrez ID		8569	79155
HPRD ID		09468	18207
Ensembl ID		ENSG00000079277	ENSG00000168884
Uniprot IDs		A8K341 Q7Z319 Q9BUB5	D6RGJ2 Q8NFZ5
PDB IDs		2HW6 2Y9Q 5WVD	5H07
Enriched GO Terms of Interacting Partners?
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