VRK2 and DTNBP1

Number of citations of the paper that reports this interaction (PubMedID 30062698)
2

Data Source:
BioGRID (pull down, enzymatic study)

		VRK2	DTNBP1
Description		VRK serine/threonine kinase 2	dystrobrevin binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Sarcoplasm Axon Growth Cone Midbody Synaptic Vesicle Membrane BLOC-1 Complex Melanosome Membrane Sarcolemma Neuron Projection Dendritic Spine Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Protein Phosphorylation Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Positive Regulation Of Neurotransmitter Secretion Negative Regulation Of Protein Kinase Activity Blood Coagulation Anterograde Axonal Transport Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Neuron Projection Development Actin Cytoskeleton Reorganization Negative Regulation Of Protein Binding Melanosome Organization Regulation Of JUN Kinase Activity Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Depression ( 33859377 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Liver enzyme levels (alkaline phosphatase) ( 33972514) Multiple myeloma ( 27363682) Serum alkaline phosphatase levels ( 33547301) Squamous cell carcinoma ( 31174203)
Interacting Genes		25 interacting genes: AQP6 ASB3 BABAM2 CCT2 CCT4 CDC42 CNTN5 DHDDS DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLD3 PTTG1 RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	58 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S3 BLOC1S5 BLOC1S6 BRF1 CAP2 CCDC146 CCDC153 CCNA2 CCND3 CMYA5 CSGALNACT1 DCTN1 DEK DGCR6L DST DTNA DTNB ELOVL7 HAUS1 HDGFL1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 KRT75 MACF1 NBEA NDN NECAB2 NUF2 NUP153 OIP5 P4HA3 PSME3 RAB11A RBSN RNF144B SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TPMT TRAF3IP1 TRIM2 TRIM27 TRIM9 VRK2 WASHC3 ZNF490
Entrez ID		7444	84062
HPRD ID		03702	06190
Ensembl ID		ENSG00000028116	ENSG00000047579
Uniprot IDs		A8K9L2 Q86Y07	A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8
PDB IDs		2V62 5UU1 6NCG
Enriched GO Terms of Interacting Partners?
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