VRK2 and BABAM2

		VRK2	BABAM2
Description		VRK serine/threonine kinase 2	BRISC and BRCA1 A complex member 2
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex	Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	Peroxisome Targeting Sequence Binding Tumor Necrosis Factor Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Phosphorylation Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Double-strand Break Repair Chromatin Organization Apoptotic Process Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Signaling Signal Transduction Response To Ionizing Radiation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Depression ( 33859377 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Blond vs. brown/black hair color ( 30531825) Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 29617998) Low density lipoprotein cholesterol levels ( 33339817) Urate levels ( 31578528) Uterine fibroids ( 31649266)
Interacting Genes		25 interacting genes: AQP6 ASB3 BABAM2 CCT2 CCT4 CDC42 CNTN5 DHDDS DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLD3 PTTG1 RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	8 interacting genes: BABAM1 GFI1B NCOA3 SHMT2 SUMO2 UBC UBE2D1 VRK2
Entrez ID		7444	9577
HPRD ID		03702	08498
Ensembl ID		ENSG00000028116	ENSG00000158019
Uniprot IDs		A8K9L2 Q86Y07	Q9NXR7
PDB IDs		2V62 5UU1 6NCG	6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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