VRK2 and CCT4

Number of citations of the paper that reports this interaction (PubMedID 24298020)
14

Data Source:
BioGRID (pull down)

		VRK2	CCT4
Description		VRK serine/threonine kinase 2	chaperonin containing TCP1 subunit 4
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex	Zona Pellucida Receptor Complex Nucleoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Projection Cell Body Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding
	Biological Process	Protein Phosphorylation Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Depression ( 33859377 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Erectile dysfunction ( 30583798) Plasma free amino acid levels ( 30659259)
Interacting Genes		25 interacting genes: AQP6 ASB3 BABAM2 CCT2 CCT4 CDC42 CNTN5 DHDDS DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLD3 PTTG1 RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	17 interacting genes: ACTA1 ACTA2 ACTB CCNE1 CCNH CCT2 CFAP52 COP1 LINC01554 MTDH OGT PRPF40A PTEN RPS6KA1 SUMO2 VRK2 WDPCP
Entrez ID		7444	10575
HPRD ID		03702	05506
Ensembl ID		ENSG00000028116	ENSG00000115484
Uniprot IDs		A8K9L2 Q86Y07	P50991
PDB IDs		2V62 5UU1 6NCG	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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