VRK2 and GJA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VRK2	GJA5
Description		VRK serine/threonine kinase 2	gap junction protein alpha 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane Protein-containing Complex	Integral Component Of Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Cell Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Domain Specific Binding Protein Serine Kinase Activity	Gap Junction Channel Activity Protein Binding Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Disordered Domain Specific Binding
	Biological Process	Protein Phosphorylation Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway	Angiogenesis Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Potassium Ion Transport Cell-cell Signaling Cell Communication By Chemical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Vasodilation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Artery Morphogenesis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of AV Node Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Purkinje Myocyte Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Vasomotion
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle	Gap junction assembly
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30940813) Ambidextrousness ( 32989287) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime nap ( 33568662) Depression ( 33859377 29700475) Epilepsy ( 25087078) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Hirschsprung disease ( 27702942) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Problematic alcohol use ( 32451486) Schizophrenia ( 28991256 25056061 19571808 29483656 27922604 30285260) Sleep duration ( 27992416 27494321) Sleep duration (oversleepers vs undersleepers) ( 27494321) Smoking initiation ( 33082346) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Atrial fibrillation ( 30061737 29892015) Cognitive performance ( 20125193) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057) PR interval ( 32439900) Triglyceride levels ( 34074324)
Interacting Genes		25 interacting genes: AQP6 ASB3 BABAM2 CCT2 CCT4 CDC42 CNTN5 DHDDS DTNBP1 GJA5 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 MMGT1 OGT PLD3 PTTG1 RBX1 TBXA2R TCP1 TMEM14B TMEM205 TMEM88	34 interacting genes: AAR2 ABHD16A BLCAP C4orf3 EMP3 FCER1G GJA1 GJB2 IGFBP5 LEPROT LEPROTL1 LHFPL2 MARK1 MFSD5 MS4A13 NIPAL3 NKG7 PGAP2 PRAF2 PRKACA RIMS3 RPRM SLC13A4 SLC30A2 SLC35F1 SLC41A1 SLC41A2 SLC66A1 TMBIM6 TMEM107 TREX1 UBQLN4 VRK2 YIPF6
Entrez ID		7444	2702
HPRD ID		03702	08699
Ensembl ID		ENSG00000028116	ENSG00000265107
Uniprot IDs		A8K9L2 Q86Y07	P36382 X5D2H9
PDB IDs		2V62 5UU1 6NCG
Enriched GO Terms of Interacting Partners?
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