TSHR and PTDSS1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		TSHR	PTDSS1
Description		thyroid stimulating hormone receptor	phosphatidylserine synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Transferase Activity L-serine-phosphatidylethanolamine Phosphatidyltransferase Activity L-serine-phosphatidylcholine Phosphatidyltransferase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Phosphatidylserine Biosynthetic Process
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Synthesis of PS
Drugs		Thyrotropin alfa	Phosphatidyl serine
Diseases
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Huntington's disease progression ( 28642124) Obesity-related traits ( 23251661) Peripheral arterial disease x type 2 diabetes interaction ( 32541925)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB	3 interacting genes: CREB3 PTEN TSHR
Entrez ID		7253	9791
HPRD ID		04537	17926
Ensembl ID		ENSG00000165409	ENSG00000156471
Uniprot IDs		A0A0A0MTJ0 P16473	P48651
PDB IDs		1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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