TSHR and TMCO3

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		TSHR	TMCO3
Description		thyroid stimulating hormone receptor	transmembrane and coiled-coil domains 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex	Integral Component Of Membrane
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Solute:proton Antiporter Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Proton Transmembrane Transport
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Thyrotropin alfa
Diseases
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Influenza A (H1N1) infection ( 26379185) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Sleep (1/3-day periodicity) ( 33075057) White blood cell count ( 32888494)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB	4 interacting genes: EGFR GLP1R HSPB1 TSHR
Entrez ID		7253	55002
HPRD ID		04537	12612
Ensembl ID		ENSG00000165409	ENSG00000150403
Uniprot IDs		A0A0A0MTJ0 P16473	A0A024RE09 Q6UWJ1
PDB IDs		1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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