TSHR and TMEM119

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		TSHR	TMEM119
Description		thyroid stimulating hormone receptor	transmembrane protein 119
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Molecular_function
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Endochondral Ossification Spermatogenesis Positive Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Positive Regulation Of Bone Mineralization Biomineral Tissue Development Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Bone Resorption Spermatid Differentiation Positive Regulation Of Bone Development
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Thyrotropin alfa
Diseases
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Acne (severe) ( 24927181) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 30054594 29235454) Optic disc size ( 31809533) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB	7 interacting genes: AQP6 CERS4 MFSD14B ODF4 SLC10A1 SLC10A6 TSHR
Entrez ID		7253	338773
HPRD ID		04537	11260
Ensembl ID		ENSG00000165409	ENSG00000183160
Uniprot IDs		A0A0A0MTJ0 P16473	Q4V9L6
PDB IDs		1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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