TSHR and SCRIB

Number of citations of the paper that reports this interaction (PubMedID 15775968)
31

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TSHR	SCRIB
Description		thyroid stimulating hormone receptor	scribble planar cell polarity protein
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex	Immunological Synapse Nucleoplasm Plasma Membrane Cell-cell Junction Adherens Junction Postsynaptic Density Basolateral Plasma Membrane Lamellipodium Cell Junction Cell Leading Edge Scrib-APC-beta-catenin Complex Myelin Sheath Abaxonal Region Presynaptic Membrane Cell-cell Contact Zone Postsynaptic Membrane Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Protein Binding Cadherin Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Establishment Of T Cell Polarity Neural Tube Closure Positive Regulation Of Receptor Recycling Cell Population Proliferation Embryo Development Synaptic Vesicle Targeting Cell Migration Cochlear Nucleus Development Polarized Epithelial Cell Differentiation Positive Regulation Of Interferon-gamma Production Establishment Of Apical/basal Cell Polarity Post-anal Tail Morphogenesis Wound Healing Positive Regulation Of Apoptotic Process Receptor Clustering Astrocyte Cell Migration Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Activated T Cell Proliferation Synaptic Vesicle Endocytosis Positive Chemotaxis Auditory Receptor Cell Stereocilium Organization Apoptotic Process Involved In Morphogenesis Mammary Gland Duct Morphogenesis Protein Localization To Adherens Junction Activation Of GTPase Activity Receptor Localization To Synapse Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport Postsynaptic Membrane To Endosome Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Asymmetric localization of PCP proteins CDC42 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs		Thyrotropin alfa
Diseases
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Menarche (age at onset) ( 25231870)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB	14 interacting genes: ACE2 APC ARHGEF7 C5AR2 EXOSC10 LPP MAPK3 OGT PRKCA STX4 TJP2 TRIP6 TSHR UBE3A
Entrez ID		7253	23513
HPRD ID		04537	06984
Ensembl ID		ENSG00000165409	ENSG00000180900
Uniprot IDs		A0A0A0MTJ0 P16473	A0A0G2JNZ2 A0A0G2JPP5 A0PJK8 Q14160
PDB IDs		1XUM 2XWT 3G04	1UJU 1WHA 1X5Q 2W4F 4WYT 4WYU 5VWC 5VWI 5VWK 6EEY 6ESP 6MS1 6MTU 6MTV 6MYE 6MYF
Enriched GO Terms of Interacting Partners?
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