TSHR and RUNDC3A

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		TSHR	RUNDC3A
Description		thyroid stimulating hormone receptor	RUN domain containing 3A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex	Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Protein Binding GTPase Regulator Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Small GTPase Mediated Signal Transduction Positive Regulation Of CGMP-mediated Signaling Regulation Of Catalytic Activity
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Thyrotropin alfa
Diseases
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB	37 interacting genes: AP1M1 AP2M1 ARMC7 CCNL2 DDX6 EIF3E ENKD1 FAM161A GEM GFI1B HTR6 LNX1 MAGEB4 MAGOHB MBD3L2 MRPL15 MYO15B PRPF31 RAP1A RAP2A RAP2B SDCBP SHANK3 SYT17 TBRG1 TEAD4 TFPT TSC1 TSGA10IP TSHR UBTFL1 USP2 ZNF250 ZNF417 ZNF587 ZNF821 ZNF835
Entrez ID		7253	10900
HPRD ID		04537	16106
Ensembl ID		ENSG00000165409	ENSG00000108309
Uniprot IDs		A0A0A0MTJ0 P16473	Q59EK9
PDB IDs		1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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