TRPC5 and PLS3

		TRPC5	PLS3
Description		transient receptor potential cation channel subfamily C member 5	plastin 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Membrane Raft	Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Filament Bundle
	Molecular Function	Actin Binding Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Calcium Ion Binding Actin Filament Binding
	Biological Process	Calcium Ion Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Membrane Hyperpolarization	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development
Pathways		TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Smoking behavior ( 19247474)	Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)
Interacting Genes		10 interacting genes: DRD2 ENKUR ITPR3 MX1 PLS3 SLC9A3R1 STMN2 STMN3 TRPC1 TRPC4	17 interacting genes: ACRV1 APP ASGR1 ATXN2 CUL4B CXCR5 FRYL LRCH2 NRSN1 OGT PTPN5 TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195
Entrez ID		7224	5358
HPRD ID		02273	02133
Ensembl ID		ENSG00000072315	ENSG00000102024
Uniprot IDs		Q9UL62	B4DPW9 P13797
PDB IDs		6YSN	1AOA 1WJO
Enriched GO Terms of Interacting Partners?
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