PLS3 and TRPC5

		PLS3	TRPC5
Description		plastin 3	transient receptor potential cation channel subfamily C member 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Actin Filament Bundle	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite Growth Cone Cation Channel Complex Calcium Channel Complex Neuronal Cell Body Membrane Raft
	Molecular Function	Calcium Ion Binding Actin Filament Binding	Actin Binding Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Actin Filament Bundle Assembly Actin Filament Network Formation Bone Development	Calcium Ion Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Nervous System Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Negative Regulation Of Dendrite Morphogenesis Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Phosphatidylserine Exposure On Apoptotic Cell Surface Regulation Of Membrane Hyperpolarization
Pathways			TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Gestational age at birth (maternal effect) ( 28877031) Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Preterm birth (maternal effect) ( 28877031)	Smoking behavior ( 19247474)
Interacting Genes		17 interacting genes: ACRV1 APP ASGR1 ATXN2 CUL4B CXCR5 FRYL LRCH2 NRSN1 OGT PTPN5 TGIF2 TRPC5 TSPAN32 WFDC2 ZBTB33 ZNF195	10 interacting genes: DRD2 ENKUR ITPR3 MX1 PLS3 SLC9A3R1 STMN2 STMN3 TRPC1 TRPC4
Entrez ID		5358	7224
HPRD ID		02133	02273
Ensembl ID		ENSG00000102024	ENSG00000072315
Uniprot IDs		B4DPW9 P13797	Q9UL62
PDB IDs		1AOA 1WJO	6YSN
Enriched GO Terms of Interacting Partners?
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