SLC15A2 and ADAM12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC15A2	ADAM12
Description		solute carrier family 15 member 2	ADAM metallopeptidase domain 12
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Spanning Component Of Plasma Membrane Extracellular Exosome Spanning Component Of Membrane	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Peptide:proton Symporter Activity Dipeptide Transmembrane Transporter Activity	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Ion Transport Protein Transport Peptidoglycan Transport Xenobiotic Transport Dipeptide Transport Innate Immune Response Renal Absorption Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Dipeptide Import Across Plasma Membrane Transport Across Blood-brain Barrier Proton Transmembrane Transport Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis
Pathways		Proton/oligopeptide cotransporters	Signaling by EGFR Invadopodia formation
Drugs		Ampicillin Cefotaxime Oxacillin Benzylpenicillin
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet count ( 32888494) Plateletcrit ( 32888494)	Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Interacting Genes		26 interacting genes: ADAM12 ANKS1A AQP1 C11orf87 CHRD ENKD1 KLHL38 KPRP KRT34 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP6-3 LMO4 NTAQ1 OTX1 PDZD3 PDZK1 PITX1 PLSCR4 SMARCC1 TENT5B TLX3 VENTX WWOX	42 interacting genes: ACTN2 ADAMTSL4 CYSRT1 DOCK1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D TUBGCP2 YES1
Entrez ID		6565	8038
HPRD ID		09088	04092
Ensembl ID		ENSG00000163406	ENSG00000148848
Uniprot IDs		Q16348	A8K6G4 O43184 U5NE98
PDB IDs		6EZI
Enriched GO Terms of Interacting Partners?
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