ADAM12 and KRTAP3-2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ADAM12	KRTAP3-2
Description		ADAM metallopeptidase domain 12	keratin associated protein 3-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane	Cytosol Keratin Filament
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Structural Molecule Activity Protein Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Positive Regulation Of Angiogenesis
Pathways		Signaling by EGFR Invadopodia formation	Keratinization
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Interacting Genes		42 interacting genes: ACTN2 ADAMTSL4 CYSRT1 DOCK1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D TUBGCP2 YES1	75 interacting genes: ADAM12 ADAMTSL3 AQP1 ARFGAP1 ATG9A C5orf60 CATSPER1 CCDC28A-AS1 CELF5 CERK CNNM3 COL8A1 CREB5 DHRS1 DUSP10 EFEMP2 FAM71C FOXD2 FRS3 GAD1 GATA1 GUCD1 HOXA1 HOXB9 HYAL2 HYPK ITGB5 KIF25-AS1 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-1 KRTAP12-2 KRTAP13-3 KRTAP15-1 KRTAP26-1 KRTAP4-12 KRTAP4-4 KRTAP9-2 KRTAP9-3 LASP1 LCE1A LCE1B LCE1F LCE2A LCE3A LCE3C LCE3D LCE3E LCE4A MAN2B2 MAPKBP1 NR1D2 NTM NUFIP2 OLIG3 OTX1 PCSK5 PLSCR3 POGZ POU4F2 PPP1R32 PRR34 R3HDM2 SLC13A5 SMARCC1 SPRY1 TBC1D16 TRIM42 TRIP13 VASN YIPF3 ZIC1 ZIM2
Entrez ID		8038	83897
HPRD ID		04092	13938
Ensembl ID		ENSG00000148848	ENSG00000212900
Uniprot IDs		A8K6G4 O43184 U5NE98	Q9BYR7
PDB IDs
Enriched GO Terms of Interacting Partners?
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